Turning energy transfer processes at the enzyme/MNP interphase by magnetic heating
he aim is to create a magnetic nanoparticles (MNP’s) toolbox with a wide range of AMF-tuned heating profiles. Their long-term stability under operation conditions (leakage of metal ions & toxicity) will be assessed.
Main objectives include:
- the modulation of MNP’s heating power by tuning several magnetic coupling parameters to obtain high temperature gradients at the enzymes surroundings regarding the bulk,
- to match the local temperature magnetically induced at the enzyme/MNPs interphase with each enzyme Topt;
- to ensure on demand or simultaneous ON/OFF thermal switching of different enzyme/MNPs conjugates.