consortium

Spanish National Research Council (CSIC)

The Spanish National Research Council is the largest public institution dedicated to research in Spain and the third largest in Europe.
Three different Institutes will participate in HOTZYMES under CSIC´s umbrella:

Aragón Materials Science Institute (ICMA)

  • coordination
  • biofunctionalization of nanomaterials and development of magnetic heating
  • applications
  • engineering surface of MNP
  • tailormade functionalization strategies for oriented and straightforward enzyme immobilization
  • investigate heat transfer/diffusion at different scale levels

Institute of Catalysis and Petrochemistry (ICP)

  • optimizing co-immobilization of enzymes within microstructured porous materials for fine control of their spatial distribution
  • integration of enzyme@MNPs conjugates within porous microbeads

Madrid Materials Science Institute (ICMM)

  • reproducible and scalable synthesis of magnetic nanoparticles related to the use of magnetic heating
  • providing different types of MNPs
  • finding correlations within magnetic features of MNPs and their heating efficiency
Valeria Grazu
Valeria Grazu
HOTZYMES lead (ICMA)
HOTZYMES lead (ICMA)
Jose Manuel Guisán-Seijas
Jose Manuel Guisán-Seijas
HOTZYMES lead (ICP)
HOTZYMES lead (ICP)
Puerto Morales
Puerto Morales
HOTZYMES lead (ICMM)
HOTZYMES lead (ICMM)
Dörte Rother
Dörte Rother
HOTZYMES lead
HOTZYMES lead
Forschungszentrum Jülich GmbH

Forschungszentrum Jülich GmbH is a member of the Helmholtz Association of German Research Centres and one of the largest interdisciplinary research centers in Europe. The team „Synthetic Enzyme Cascades“at the Institute of Bio- and Geosciences 1: Biotechnology is led by Dörte Rother and focuses on the development of value generating processes to fine chemicals using synthetic enzyme cascades. Here, biologists, chemists and engineers combine catalysts to multi-step biotransformations, which do not occur conjunct in nature. Rational enzyme engineering, reaction optimisation and process design is used to optimally gain both, economically and ecologically efficient cascades. This aims to bridge between fundamental research and industrially relevant biocatalysis.


tasks

  • achieving on-demand regulation of a one-pot multi-enzyme cascade to synthesize stereopure tetrahydroisoquinolines
Bernd Nidetzky
Bernd Nidetzky
HOTZYMES lead
HOTZYMES lead
Technische Universität Graz

The Institute of Biotechnology and Biochemical Engineering (www.biote.tugraz.at) is the main Austrian university institution for basic and applied research at the interface of biological sciences and process engineering. The aim is to achieve innovative solutions for efficient and accelerated process development in biotechnology using an integrated scientific-technological approach that combines modern methods of molecular and process bioengineering.


tasks

  • bringing in expertise on carbohydrates and biocatalytic methods of their synthesis
  • enabling the operation of simultaneous enzymatic reactions with unpaired optimal temperatures for conversion of sucrose into different products (α-glucosyl-2-glycerate, cellobiose/cello-oligosaccharides)
Fernando Lopez-Gallego
Fernando Lopez-Gallego
HOTZYMES lead
HOTZYMES lead
University of Zaragoza

The University of Zaragoza is the main centre of technological innovation in the Ebro Valley. Within the areas of Engineering and Technology, the team “Heterogeneous Biocatalysis Laboratory“ lead by Fernando Lopez-Gallego develops key enabling technologies for in vitro synthetic biology. To achieve they bridge the chemistry and the biology utilizing multidisciplinary tools that involve molecular biology, enzymology and material chemistry.


tasks

  • engineering the surface of different enzymes, immobilizing them on magnetic nanoparticles
  • protein engineering to enable the control enzyme orientation, enzyme-particle distance and valency of the attachment during the immobilization protocol
Giovanni Bernardini
Giovanni Bernardini
HOTZYMES lead
HOTZYMES lead
Universita Degli Studi Dell'Insubria

The Department of Biotechnology and Life Sciences (DBSV) brings together biology and biotechnology to medical sciences in a single environment with the aim to build synergies between basic and applied sciences by means of a multidisciplinary approach. This choice has allowed the achievement of good results both in terms of research and teaching. In this context, the laboratory of Cell Biology lead by Giovanni Bernardini has focused its interest in the study of the interactions of metal nanoparticles with biological systems.


tasks

  • in charge of toxicity of MNPs and hybrid particles
  • investigate if leakage of metal ions occurs due to their extensive submission (long time periods, several reuse cycles) to AMF
Nicolas Cassinelli
Nicolas Cassinelli
HOTZYMES lead
HOTZYMES lead
Nanoscale Biomagnetics Sociedad Limitada

nanoScale Biomagnetic SL (nB) is a technology-based SME company focused on the development and commercialization of instrumentation for magnetic heating of nanoparticles. The company was founded in 2008 as spin-off company of the Magnetic Hyperthermia Group of the Institute of Nanoscience of Aragón of the University of Zaragoza (UZ) in Spain lead by Professor Gerardo Goya, following the successful design and development of a first prototype instrument for the study of magnetic heating of nanoparticles for magnetic hyperthermia treatment (MHT), engineered by Eng. Nicolas Cassinelli. Since then, the company has developed the initial prototype instrument into a commercially available product series of AMF-application devices, the DM100 series, with the support of public and private capital. Currently, the company is worldwide leader on its market and its products are the top-shelf choice for researcher all across the globe. During the last years, nB started the exploration of the technologies not related to therapy, such as catalysis by AMF.


tasks

  • in charge of designing, building, prototyping and validating a new concept of AMF applicators capable to trigger enzyme activation by AMF
Martin Walpot
Martin Walpot
HOTZYMES lead
HOTZYMES lead
acib GmbH

The Austrian Centre of Industrial Biotechnology (acib) is an international competence centre specialized on bridging the gap between academic and industrial research.


tasks

  • Dissemination, communication (create awareness, inform the public about the project and EU funded research)
  • Exploitation
  • Technology transfer intermediary
  • Provides a broad industrial network in biotech industry

The research for this work has received funding from the European Union (EU) project HOTZYMES (grant agreement n° 829162) under  EU’s Horizon 2020 Programme  Research and Innovation actions H2020-FETOPEN-2018-2019-2020-01

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